Silas Volkmire is in Battletoads in Battlemaniacs as the secondary villain, though the 'Toads never fight him directly. In Battlemaniacs, he uses Psicone's TRIPS 21 system to send Psyko-Pigs out and capture Michiko and Zitz. Pimple and Rash are then forced to play within Silas's game. In the final part of the game, Silas slips back to Earth and the 'Toads have to destroy his escape ship before it escapes. Whether or not they're successful will result in different endings.
Prior to Battlemaniacs, Silas appeared in the Battletoads comic as an employee of the Psicone Corporation. Though he prides himself on having created the Games Generator, he is jealous over the more visible success of the Battletoads and their "players", Dave, Morgan, and George. Out of his jealousy, Silas brings the Dark Queen into his world and allies with her by implanting a virus into the Games Generator, which traps the trio as Battletoads and leaves them in the Dark Queen's universe. He later appears in the comic to narrate a scene where the 'Toads fall into the lava of his namesake stage, "Volkmire's Inferno". Finding it hilarious, Silas continues to loop the scene ad nauseum. How he might have changed into the skeletal monster he appears as in Battlemaniacs is never explained, though he may have created an avatar similar to the Battletoads of their original controllers of Dave, George and Morgan.